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Dr.Chang BRIC 한.빛.사 Research Article

스탠드업테라퓨티스
2022.06.23 10:43 1,187 0

본문

Electromagnetized gold nanoparticles improve neurogenesis and cognition in the aged brain
열기 Authors and Affiliations

Abstract

Adult neurogenesis is the lifelong process by which new neurons are generated in the dentate gyrus. However, adult neurogenesis capacity decreases with age, and this decrease is closely linked to cognitive and memory decline. Our study demonstrated that electromagnetized gold nanoparticles (AuNPs) promote adult hippocampal neurogenesis, thereby improving cognitive function and memory consolidation in aged mice. According to single-cell RNA sequencing data, the numbers of neural stem cells (NSCs) and neural progenitors were significantly increased by electromagnetized AuNPs. Additionally, electromagnetic stimulation resulted in specific activation of the histone acetyltransferase Kat2a, which led to histone H3K9 acetylation in adult NSCs. Moreover, in vivo electromagnetized AuNP stimulation efficiently increased hippocampal neurogenesis in aged and Hutchinson-Gilford progeria mouse brains, thereby alleviating the symptoms of aging. Therefore, our study provides a proof-of-concept for the in vivo stimulation of hippocampal neurogenesis using electromagnetized AuNPs as a promising therapeutic strategy for the treatment of age-related brain diseases.

Keywords : Gold nanoparticles, Electromagnetized field, Neurogenesis, Neural stem cells, Aging

논문정보
- 형식: Research article
- 게재일: 2021년 09월 (BRIC 등록일 2021-09-29)
- 연구진: 국내연구진태극기


https://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=71869&idauthorid=35771&ttype=0 

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